Keith Ferguson

Megamind (voice)

Laura Post

Roxanne Ritchi (voice)

Josh Brener

OI' Chum (voice)

Maya Tuttle

Keiko Morita (voice)

Emily Tuñon

Lady Doppler (voice)

Talon Warburton

Lord Nighty-Knight (voice)

Scott Adsit

Pierre Pressure (voice)

Chris Sullivan

Behemoth (voice)

Tony Hale

Mel / Mr. Donut / TV Announcer (voice)

Adam Lambert

Machiavillain (voice)

Jeanine Mason

Christina Christo / Hostess (voice)

Michael Beattie

Eccentric Eddie (voice)